Five main Reasons for Diabetes - Health Facts 1. Insulin Resistance Insulin resistance is the first step toward diabetes. When insulin levels drop, glucose levels rise. Glucose is the primary fuel for cells. If the body does not produce enough insulin, then glucose cannot enter the cells and stays in the bloodstream. In time, if insulin resistance continues, the pancreas may have to work harder to make more insulin. Eventually, the pancreas becomes exhausted and produces less insulin than normal. 2. Obesity Obesity is a major risk factor for type 2 diabetes. Overweight people tend to have higher insulin levels than those who are leaner. Fat cells take up more space than muscle cells. As far as cells expand, they crowd out the space where insulin- producing beta cells should live. 3. Genetics Some people inherit genes that cause them to develop diabetes at a young age. Other people develop diabetes later in life after having children. Still, others develop diabetes